Department of Zoology

Paul J. Schaeffer
Assistant Professor
Ph.D. Northern Arizona Univ., 2000
animal energetics and muscle physiology

Office:
288 PSN
Phone:
529-3624
Email:
schaefpj@muohio.edu

Home Page:
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Office Hours:
  Monday . . . . See Niihka
  Tuesday . . . .
  Wednesday . .
  Thursday. . . .
  Friday. . . . . . Others by appt.

Biographical Information:

The primary focus of the Schaeffer lab is the study of muscle plasticity and its implications in organismal energy balance. Experimental approaches range from cell and molecular studies to measurements of physiological activity in the field. This very broad interest can best be divided into 2 more specific research programs.

One of these programs is to utilize the tools of molecular biology to investigate the roles of specific regulatory factors in the control of muscle phenotype in health and disease. Muscle phenotypic plasticity is important in the maintenance of normal metabolic regulation, best demonstrated by the loss of this trait in metabolic diseases such as the metabolic syndrome and diabetes. Although the dynamic regulation of muscle fuel uptake and oxidation is very well appreciated, there is considerable debate about whether loss of normal metabolic function is a causative agent or an outcome of disease. We study the interaction of activity and lipid metabolism in the regulation and maintenance of muscle function using genetically modified mouse and cell culture models.

Another program utilizes comparative physiology in an attempt to delineate the ways in which evolution has shaped muscle and energetic physiology in order to identify the common “design principles” or constraints that operate on animals (primarily tetrapods) in general. Much is known about the physiological responses of muscle to alterations in activity or demand in numerous mammalian species. How and to what extent this is true in other tetrapods (or in marsupials) remains under-investigated. Further, even in mammalian model species such as rats and mice, the control of acclimative responses is poorly understood. I propose (as have many before me) that by describing adaptations of muscle-metabolic physiology across evolutionary radiations, that both the events common to all species as well as unique adaptations will inform our understanding of muscle biology.



Courses Taught:

  1. ZOO 305: Animal Physiology
  2. ZOO 453: Animal Physiological Ecology
  3. ZOO 492: Seminar on Muscle Plasticity
  4. ZOO 710: Seminar on Allometry


Recent Publications:

  1. Schaeffer PJ, Desantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers DM, Kelly DP. Impaired contractile function and calcium handling in hearts of cardiacspecific calcineurin b1-deficient mice. Am. J. Physiol., 297: H1263-1273, 2009.

  2. Schaeffer PJ, Nichols SD, Lindstedt SL. Chronic electrical stimulation drives mitochondrial biogenesis in skeletal muscle of a lizard, Varanus exanthematicus. J. Exp. Biol., 210: 3356-3360, 2007.

  3. Schaeffer, P.J., J.J. Villarin, D.J. Pierotti, D.P. Kelly, and S.L. Lindstedt. Cost of Transport is Increased after Cold Exposure in Monodelphis domestica: Training for Inefficiency. J. Exp. Biol., 208: 3159-3167, 2005.

  4. Schaeffer, P.J., A.R. Wende, C.J. Magee, T. Leone, J.R. Neilsen, T.C. Leone, F. Chen and D.P. Kelly. Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle. J. Biol. Chem., 279: 39593-39603, 2004.

  5. Schaeffer, P.J., J.J. Villarin, and S.L. Lindstedt. Chronic cold exposure increases skeletal muscle oxidative structure and function in Monodelphis domestica, a marsupial lacking brown adipose tissue. Physiol. Biochem. Zool., 76: 877-887, 2003.