Department of Zoology

James M. Janik
Professor
Ph.D. Rutgers University 1990
neuroendocrinology

Office:
109 Levey
290 PSN

Lab:
253K PSN

Phone:
727-3230
529-3174


529-3161
Email:
janikjm@MUOhio.edu
Office Hours:
  Monday . . . . Others by appt.
  Tuesday . . . .
  Wednesday . . 12:00 - 12:45
  Thursday. . . .
  Friday. . . . . . 12:00 - 12:45

Biographical Information:

James Janik is a neuroendocrinologist whose primary interest is regulatory control of anterior pituitary hormone secretions. He is particularly interested in the neuroregulatory role played by the Endogenous Opioid Peptides and the recently discovered, novel neuropeptide, Orphanin FQ. Using the rat as their primary research model, students in his laboratory investigate mechanisms of hormonal control under several different physiological conditions at both the in vivo and in vitro levels. A major thrust of the work is determining the impact of gender and reproductive state, in particular lactation, on hormonal control mechanisms. Dr. Janik often works in collaboration with Dr. Phyllis Callahan, another neuroendocrinologist in the Department of Zoology.

Students in his laboratory learn a wide variety of investigative techniques including: radioimmunoassay (RIA) to quantify hormone concentrations; electrochemical detection of catecholamines following high pressure liquid chromatographic separation to quantify neurotransmitter content in specific brain regions; analgesia testing as a behavioral index of opiate activity and pain perception; immunocytochemistry to determine peptide localization and neural activation; perfusion of isolated tissues, such as hypothalamus and anterior pituitary to investigate cellular control mechanisms; and small animal surgery including stereotaxic surgery.



Courses Taught:

  1. Human Anatomy and Physiology I (Zoo 171)
  2. Human Anatomy and Physiology II (Zoo 172)
  3. Graduate Seminar (ZOO 710)


Recent Publications:

  1. Russell JM, E Murphree, J Janik and P Callahan. Effects of steroids and nitric oxide on pituitary hormone release in ovariectomized, peripubertal rats. Reproduction, In Press, 2005.

  2. Brown AM, JM Janik, ES Murphree, R King and P Callahan. Effects of cyclic steroid hormone replacement on prolactin and luteinizing hormone surges in female rats. Reproduction, 128:373-378, 2004.

  3. Janik J, T Krupica, L Dengler, E Murphree and P Callahan. Acetyl-RYYRIK-NH2, a purported Orphanin FQ antagonist does not block the Orphanin FQ induced prolactin secretory response in female rats. Neuroscience Letters, 345:149-152, 2003.

  4. Bryant W, P Callahan, E Murphree and J Janik [Phe1Y(CH2-NH)Gly2]NC(1-13)NH2, does not antagonize OFQ induced prolactin release. Brain Research Bulletin 57:695-703, 2002.