Department of Zoology

Lori G. Isaacson
Ph.D. Michigan State University, 1986
neuronal survival, aging and neurodegeneration

280 PSN

267D PSN


Office Hours:
  Monday . . . .
  Tuesday . . . . 10:45 - 12:00
  Wednesday . .
  Thursday. . . . 10:45 - 12:00
  Friday. . . . . . Others by appt.

Biographical Information:

Lori Isaacson is a neuroscientist interested in the regulation of neuronal survival and the mechanisms of aging and neurodegeneration. Specifically, she examines the role of growth factors called neurotrophins in the regulatory influences on adult neurons. Students in her lab learn cellular and molecular techniques to examine the influences of the neurotrophins nerve growth factor and neurotrophin-3 on the expression of neurotransmitters and receptors in the adult and aged nervous system. With funding from the National Institutes of Health, she is currently investigating the mechanisms involved in the survival and degeneration of sympathetic and sensory neurons using confocal and electron microscopy, immunohistochemistry, ELISA, RT-PCR and Western blot analysis.

Courses Taught:

  1. Neuroanatomy (ZOO 457/557)
  2. Functional Microanatomy (ZOO 328)
  3. Graduate Seminar in Neuroscience (ZOO 710)
  4. Human Physiology (ZOO 161)

Recent Publications:

  1. Randolph, C.L., M.A. Bierl, and L.G. Isaacson. 2007. Regulation of NGF and NT-3 protein expression in peripheral targets by sympathetic input. Brain Res.1144: 59-69.

  2. Kaur, G., J. Janik, L.G. Isaacson, P. Callahan. 2007. Estrogen regulation of neurotrophin expression in sympathetic neurons and vascular targets. Brain Res. 1139: 6-14.

  3. Bierl, M.A. and L.G. Isaacson. 2007. Increased NGF proforms in aged sympathetic neurons and their targets. Neurobiol. of Aging 28:122-134.

  4. Scarborough, D. and L.G. Isaacson. 2006. A hypothetical anatomical model to describe the aberrant gag reflex observed in a clinical population of orally deprived children. Clinical Anat. 19:640-644.

  5. Bierl, M.A., E.E. Jones, K.A. Crutcher, L.G. Isaacson. 2005. ‘Mature’ nerve growth factor is a minor species in most peripheral tissues. Neurosci. Letters 380: 133-137.